abstract：INTRODUCTION:123I-MIBG is the most commonly used radiopharmaceutical to depict cardiac sympathetic innervation. The purpose of this study was to validate the feasibility of 131I-MIBG as an alternative myocardial sympathetic imaging probe in differential diagnosis of Parkinsonism. METHODS:We recruited 17 patients with ...

journal_title：Parkinsonism & related disorders

authors： Xu D,Zhu W,Huo L,Zhu S,Li F,Wang H

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Glucocerebrosidase (GBA) gene variants are associated with the development of the Lewy body disorders (LBD) Parkinson disease (PD) and dementia with Lewy bodies (DLB). Idiopathic REM sleep behavior disorder (IRBD) represents prodromal LBD in most instances. We investigated whether GBA variants are overrepr...

journal_title：Parkinsonism & related disorders

authors： Gámez-Valero A,Iranzo A,Serradell M,Vilas D,Santamaria J,Gaig C,Álvarez R,Ariza A,Tolosa E,Beyer K

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Mutations in the LRRK2 and alpha-synuclein (SNCA) genes are well-established causes of autosomal dominant Parkinson's disease (PD). However, their frequency differs widely between ethnic groups. Only three studies have screened all coding regions of LRRK2 and SNCA in European samples so far. In Turkey, the...

journal_title：Parkinsonism & related disorders

authors： Kessler C,Atasu B,Hanagasi H,Simón-Sánchez J,Hauser AK,Pak M,Bilgic B,Erginel-Unaltuna N,Gurvit H,Gasser T,Lohmann E

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classifi...

journal_title：Parkinsonism & related disorders

authors： van Uem JMT,Cerff B,Kampmeyer M,Prinzen J,Zuidema M,Hobert MA,Gräber S,Berg D,Maetzler W,Liepelt-Scarfone I

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Gait dysfunction is a common symptom of Parkinson's disease that can cause significant disability and put patients at risk for falls. These symptoms show variable responsiveness to dopaminergic therapy. OBJECTIVE:To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltransphera...

journal_title：Parkinsonism & related disorders

authors： Miller NS,Chou KL,Bohnen NI,Müller MLTM,Seidler RD

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Although essential tremor (ET) is commonly encountered in clinical practice, historically, there has been considerable disagreement as how to best define it, and now with a growing sense of its clinical complexity, how to best encapsulate it. Here, I draw attention to five issues of current uncertainty. MET...

journal_title：Parkinsonism & related disorders

authors： Louis ED

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Essential tremor (ET) and Parkinson's disease (PD) are common disorders especially in the aging population and can have overlapping features that can make it difficult to differentiate between the two. In addition, a possible overlap from a pathophysiological standpoint has been often advocated in the past...

journal_title：Parkinsonism & related disorders

authors： Algarni M,Fasano A

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Conventional outcome measures (COMs) in Parkinson's disease (PD) refer to rating scales, questionnaires, patient diaries and clinically-based tests that do not require specialized equipment. METHODS:It is timely at this juncture - as clinicians and researchers begin to grapple with the "invasion" of digital...

journal_title：Parkinsonism & related disorders

authors： Lim SY,Tan AH

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural instability and tremor. Several pathologic processes can produce this syndrome, but neurodegeneration accompanied by neuronal inclusions composed of α-synuclein (Lewy bodies) is considered the typical pathologic correlate of PD. ...

journal_title：Parkinsonism & related disorders

authors： Dickson DW

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:In patients with GTP-cyclohydrolase deficient dopa-responsive dystonia (DRD) the occurrence of associated non-motor symptoms (NMS) is to be expected. Earlier studies report conflicting results with regard to the nature and severity of NMS. The aim of our study was to investigate the prevalence of psychiatric...

journal_title：Parkinsonism & related disorders

authors： Timmers ER,Kuiper A,Smit M,Bartels AL,Kamphuis DJ,Wolf NI,Poll-The BT,Wassenberg T,Peeters EAJ,de Koning TJ,Tijssen MAJ

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS:Eighty-one consecutive de novo PD patients ...

journal_title：Parkinsonism & related disorders

authors： Siciliano M,Trojano L,De Micco R,De Mase A,Garramone F,Russo A,Tedeschi G,Tessitore A

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Recent evidence suggests deep brain stimulation can alter impulse control. Our objective was to prospectively evaluate the effects of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation on impulse control disorders (ICDs) in the setting of a conservative dopamine reduction s...

journal_title：Parkinsonism & related disorders

authors： Rossi PJ,De Jesus S,Hess CW,Martinez-Ramirez D,Foote KD,Gunduz A,Okun MS

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Head tremor is a common feature in cervical dystonia (CD) and often less responsive to botulinum neurotoxin (BoNT) treatment than dystonic posturing. Ultrasound allows accurate targeting of deeper neck muscles. METHODS:In 35 CD patients with dystonic head tremor the depth and thickness of the splenius cap...

journal_title：Parkinsonism & related disorders

authors： Schramm A,Huber D,Möbius C,Münchau A,Kohl Z,Bäumer T

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Nocturnal hypokinesia is a common symptom in Parkinson's disease (PD), negatively affecting quality of life of both patients and caregivers. However, evidence-based treatment strategies are limited. OBJECTIVE:To evaluate the efficacy of rotigotine transdermal patch, using a wearable sensor, in the managemen...

journal_title：Parkinsonism & related disorders

authors： Bhidayasiri R,Sringean J,Chaiwong S,Anan C,Penkeaw N,Leaknok A,Boonpang K,Saksornchai K,Rattanachaisit W,Thanawattano C,Jagota P

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Psychosis is one of the common non-motor symptoms of PD, which substantially worsens the quality of life. Hence, it is important to identify factors that are associated with early onset of psychosis in PD. In order to identify those factors, the current study aims to compare various demographic and clinica...

journal_title：Parkinsonism & related disorders

authors： Lenka A,George L,Arumugham SS,Hegde S,Reddy V,Kamble N,Yadav R,Pal PK

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To investigate the indications and the outcomes of gastrostomy tube insertion in patients with parkinsonian syndromes. METHODS:Consecutive patients with Parkinson's disease or atypical parkinsonism, seen in two French tertiary referral movement disorders centers, that received gastrostomy tube insertion (GTI...

journal_title：Parkinsonism & related disorders

authors： Marois C,Amador MDM,Payan C,Lacomblez L,Bonnet AM,Degos B,Corvol JC,Vidailhet M,Le Forestier N,Mesnage V,Grabli D

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Traditionally the risk of Parkinson's has been considered to increase monotonically with age, although there is evidence that prevalence and incidence may decrease in the oldest old. To examine this further we estimated the national prevalence and incidence of Parkinson's in New Zealand, using drug-tracing m...

journal_title：Parkinsonism & related disorders

authors： Myall DJ,Pitcher TL,Pearson JF,Dalrymple-Alford JC,Anderson TJ,MacAskill MR

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether dopamine transporter (DAT) binding, as measured with single photon emission computed tomography (SPECT), can be used to predict mortality in patients with Parkinson's disease (PD). METHODS:A total of 162 patients with PD and abnormal [I-123]FP-CIT SPECT were clinically followed for a m...

journal_title：Parkinsonism & related disorders

authors： Mäkinen E,Joutsa J,Vahlberg T,Kaasinen V

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Orexin is a neuropeptide that plays a key role in maintaining a state of arousal, and possibly associates with sleep apnea syndrome (SAS). Reduced orexin immunoreactivity has been reported in various neurologic conditions such as narcolepsy, Alzheimer's disease, Lewy body disease and multiple system atroph...

journal_title：Parkinsonism & related disorders

authors： Mishima T,Kasanuki K,Koga S,Castanedes-Casey M,Wszolek ZK,Tsuboi Y,Dickson DW

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Orthostatic myoclonus (OM) is a recognized syndrome of gait unsteadiness accompanied by lower limb myoclonus provoked by the assumption of an upright posture. OM typically affects the elderly and is often associated with neurodegenerative disease. We sought to review the clinical and electrophysiologic cha...

journal_title：Parkinsonism & related disorders

authors： Cutsforth-Gregory JK,Hammack JE,Matsumoto JY

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:No effective treatment for tardive dystonia (TD) has been well established. Deep brain stimulation (DBS) can ameliorate motor manifestations in primary dystonia, and may also be an effective approach for TD. OBJECTIVES:This study aimed to illuminate the long-term efficacy and safety of subthalamic nucleus (...

journal_title：Parkinsonism & related disorders

authors： Deng ZD,Li DY,Zhang CC,Pan YX,Zhang J,Jin H,Zeljec K,Zhan SK,Sun BM

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:The Montreal Cognitive Assessment (MoCA) is a frequently utilized cognitive screening tool that has attractive clinical attributes when utilized in individuals with Parkinson's disease. However, the construct validity of this instrument has not been well-characterized in Parkinson's samples. The purpose of...

journal_title：Parkinsonism & related disorders

authors： Benge JF,Balsis S,Madeka T,Uhlman C,Lantrip C,Soileau MJ

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:This study of thalamic deep brain stimulation (DBS) investigated whether a novel constant-current device improves tremor and activities of daily living (ADL) in patients with essential tremor (ET). METHODS:A prospective, controlled, multicenter study was conducted at 12 academic centers. We investigated t...

journal_title：Parkinsonism & related disorders

authors： Wharen RE Jr,Okun MS,Guthrie BL,Uitti RJ,Larson P,Foote K,Walker H,Marshall FJ,Schwalb J,Ford B,Jankovic J,Simpson R,Dashtipour K,Phibbs F,Neimat JS,Stewart RM,Peichel D,Pahwa R,Ostrem JL,SJM DBS ET Study Group.

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:To report the results of a national survey aimed at quantifying the current level of diffusion of Levodopa/carbidopa intestinal gel (LCIG) in Italy. METHODS:Sixty Parkinson's Disease (PD) specialists in Italy were invited to complete a survey covering issues on clinical and practical aspects of LCIG therapy...

journal_title：Parkinsonism & related disorders

authors： Sensi M,Cossu G,Mancini F,Pilleri M,Zibetti M,Modugno N,Quatrale R,Tamma F,Antonini A,ITALIAN LEVODOPA CARBIDOPA INTESTINAL GEL WORKING GROUP.

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:Neurotrophic factors (NTFs) have been evaluated for neuroprotective effects in Parkinson's disease (PD). However, clinical trials examining the efficacy of intracerebral administration of NTFs on motor symptoms in PD have produced mixed results, and are thus inconclusive. The objective of this systematic r...

journal_title：Parkinsonism & related disorders

authors： Hegarty SV,Lee DJ,O'Keeffe GW,Sullivan AM

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Mutations in the GBA gene are associated with Parkinson's disease (PD). A definite description of the clinical characteristics of PD patients who are compound heterozygotes or homozygotes for mutations in the GBA gene (GD-PD) requires further elucidation. METHODS:We assessed motor, cognitive, olfactory and a...

journal_title：Parkinsonism & related disorders

authors： Thaler A,Gurevich T,Bar Shira A,Gana Weisz M,Ash E,Shiner T,Orr-Urtreger A,Giladi N,Mirelman A

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Punctual delivery of dopaminergic medication to Parkinson's disease (PD) patients may be important in optimizing disease control. We tested the hypothesis that prompt delivery of l-dopa medications to emergency hospital inpatients was associated with a decreased length of stay in hospital. METHODS:The study...

journal_title：Parkinsonism & related disorders

authors： Skelly R,Brown L,Fogarty A

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). However, only few cases carrying LRRK2 mutations have been reported in Taiwanese PD patients. METHODS:We used targeted next generation sequencing (NGS), covering 24 candidate genes involved in neu...

journal_title：Parkinsonism & related disorders

authors： Fan TS,Wu RM,Chen PL,Chen TF,Li HY,Lin YH,Chen CY,Chen ML,Tai CH,Lin HI,Lin CH

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Effects on non-motor symptoms, mainly cognitive and psychiatric side effects, could influence the decision for either globus pallidus pars interna (GPi) or subthalamic nucleus (STN) deep brain stimulation (DBS) for patients with Parkinson's disease (PD). OBJECTIVE:1) To compare cognitive and psychiatric out...

journal_title：Parkinsonism & related disorders

authors： Boel JA,Odekerken VJ,Schmand BA,Geurtsen GJ,Cath DC,Figee M,van den Munckhof P,de Haan RJ,Schuurman PR,de Bie RM,NSTAPS study group.

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To examine the tolerability and effectiveness of propranolol in treating tardive dyskinesia (TD). BACKGROUND:TD is a disabling, often irreversible, movement disorder that results from chronic therapy with dopamine receptor blocking drugs. There are no treatments currently approved for this disorder. Proprano...

journal_title：Parkinsonism & related disorders

authors： Hatcher-Martin JM,Armstrong KA,Scorr LM,Factor SA

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Early Onset Parkinson's Disease (EOPD) is genetically heterogeneous. PARK2 mutations are the commonest cause of autosomal recessive EOPD followed by PINK1.DJ1 mutations is rare and there is scarce literature on its phenotype and long term outcome. OBJECTIVES:We undertook a retrospective study to determine...

journal_title：Parkinsonism & related disorders

authors： Abbas MM,Govindappa ST,Sudhaman S,Thelma BK,Juyal RC,Behari M,Muthane UB

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Tremor is frequently associated with dystonia, but its pathophysiology is still unclear. Dysfunctions of cerebellar circuits are known to play a role in the pathophysiology of action-induced tremors, and cerebellar impairment has frequently been associated to dystonia. However, a link between dystonic trem...

journal_title：Parkinsonism & related disorders

authors： Antelmi E,Di Stasio F,Rocchi L,Erro R,Liguori R,Ganos C,Brugger F,Teo J,Berardelli A,Rothwell J,Bhatia KP

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:To explore the microstructural integrity of the optic nerve and its role as a cognitive predictor in patients with de novo Parkinson's disease (PD) using diffusion tensor image-based magnetic resonance scans. METHODS:We enrolled 82 patients with de novo PD, 36 patients with drug-induced parkinsonism (DIP), a...

journal_title：Parkinsonism & related disorders

authors： Lee JJ,Shin NY,Lee Y,Lee SK,Sohn YH,Lee PH

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:A novel homozygous missense mutation (c.773G > A, p.Arg258Gln) in Synaptojanin 1 (SYNJ1, 21q22.2) has recently been reported in two Italian and one Iranian consanguineous families with autosomal recessive juvenile Parkinsonism (ARJP). Contribution of this synaptic gene related to Parkinsonism phenotypes in o...

journal_title：Parkinsonism & related disorders

authors： Kirola L,Behari M,Shishir C,Thelma BK

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:aim of the study was to evaluate the presence of the Obsessive Compulsive Personality Disorder (OCPeD) in Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP) and Essential Tremor (ET) and in a group of healthy subjects. METHODS:patients affected by MSA, PSP and ET diagnosed according to cu...

journal_title：Parkinsonism & related disorders

authors： Nicoletti A,Luca A,Luca M,Donzuso G,Mostile G,Raciti L,Contrafatto D,Dibilio V,Sciacca G,Cicero CE,Vasta R,Petralia A,Zappia M

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:To determine cortical grey matter (GM) changes and their clinical and biochemical correlates in patients with Wilson's disease using voxel based morphometry (VBM). METHODS:Clinical and imaging data of 10 patients (all male, mean age 16.0 ± 6.3years) with Wilson's Disease were analyzed. T1W volumetric MRI da...

journal_title：Parkinsonism & related disorders

authors： Stezin A,George L,Jhunjhunwala K,Lenka A,Saini J,Netravathi M,Yadav R,Pal PK

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:The diagnosis of progressive supranuclear palsy is often challenging early in the course of the disease, when clinical signs of the condition may be less apparent and patients do not clearly meet diagnostic criteria. In this study, we examine a potential radiographic marker in progressive supranuclear pals...

journal_title：Parkinsonism & related disorders

authors： Owens E,Krecke K,Ahlskog JE,Fealey R,Hassan A,Josephs KA,Klassen B,Matsumoto J,Bower J

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Two phase3 studies (SP512; SP513) involving mostly Caucasian patients showed that rotigotine (≤8 mg/24 h) was efficacious and welltolerated in early-stage Parkinson's disease (PD). We report results from a phase 3 study (SP0914/NCT01646268) investigating rotigotine in Chinese patients with early-stage PD. ...

journal_title：Parkinsonism & related disorders

authors： Zhang ZX,Shang HF,Hu X,Chen S,Zhao Z,Du X,Surmann E,Bauer L,Asgharnejad M

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:The frequency and causes of hypertrophic olivary degeneration (HOD) are unknown. We compared the clinical and radiological characteristics of unilateral HOD and bilateral HOD. METHODS:We performed a search of a radiologic report database for patients who were radiologically diagnosed as having HOD. This d...

journal_title：Parkinsonism & related disorders

authors： Konno T,Broderick DF,Tacik P,Caviness JN,Wszolek ZK

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. METHOD...

journal_title：Parkinsonism & related disorders

authors： Chahine LM,Xie SX,Simuni T,Tran B,Postuma R,Amara A,Oertel WH,Iranzo A,Scordia C,Fullard M,Linder C,Purri R,Darin A,Rennert L,Videnovic A,Del Riva P,Weintraub D

更新日期：2016-06-01 00:00:00